Clinical feature: 

Definition: Central diabetes insipidus results from inappropriate production of the antidiuretic hormone arginine vasopressin and can ameliorated by hormone supplementation.

Diagnostics: 

Differential: There are several aquired conditions which result in syndrome of inappropriate antidiuretic hormone secretion (SIADH).
   See also the general page of diabetes insipidus for further differentials.  » » » 

Literature: 

Ito M et al. (1991) A single base substitution in the coding region for neurophysin II associated with familial central diabetes insipidus.
Bahnsen U et al. (1992) A missense mutation in the vasopressin-neurophysin precursor gene cosegregates with human autosomal dominant neurohypophyseal diabetes insipidus.
Ito M et al. (1993) Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus.
Grant FD et al. (1998) Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant.