Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Glomerulonephritis is a collection of disorders with different pathogeneses and histomorphologies whose common denominator is inflammation of the glomeruli, the fitration barrier of the kidney. Often glomerulonephrites are caused by immunological disturbances and therefore increasingly genetic disorders are found to be essential for its development.
Basic symptoms are proteinuria and glomerular hematuria. Theres two main symptoms underly the clinical classifiaction into nephrotic and nephritic kidney disease.
Histomorphology allows a more accurate diagnosis and classification into subtypes that differ by histomorphology. Histomorphological studies also allow immunehistochenistry which comes close to a pathogenetic classification.
Most recent genetic fidings allow an even deeper pathognetic classification.
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