Glomerulosclerosis

Glomerulosclerosis describes histomorphological alterations of the kidney characterized by glomerular fibrosis and scars. This is the common end point in several pathological processes affecting the glomerulus. It may occur focal, only some glomeruli altered, and segmental, only parts of the glomerulus affected.

Clinical Findings

Proteinuria, glomerular haematuria, and progressive decline of renal function are the dominating clinical symptoms, which start in teenage years and may develop to end-stage renal disease in some individuals.

Systematic

Hereditary glomerular disease
	Fibronectin glomerulopathy
	Glomerulonephritis
	Glomerulosclerosis
		Familial partial lipodystrophy type 2
			LMNA
		Focal, segmental glomerulosclerosis (FSGS)
			ALG13
			ARHGAP24
			CLU
			Hereditary FSGS type 1
				ACTN4
			Hereditary FSGS type 2
				TRPC6
			Hereditary FSGS type 3
				CD2AP
			Hereditary FSGS type 4
				APOL1
			Hereditary FSGS type 5
				INF2
			Hereditary FSGS type 6
				MYO1E
			Hereditary FSGS type 7
				PAX2
			ITGA9
			LAMA5
			NXF5
		Frasier syndrome
			WT1
		Glycogen storage disease 1A
			G6PC
		Norum disease
			LCAT
	Lipoprotein glomerulopathy
	Myoclonus-nephropathy syndrome
	Nephritic syndrome
	Nephrotic syndrome