MODY5 diabetes

MODY5 diabetes is an autosomal dominant disorder of glucose metabolism and kidney development. The disease is caused by mutations of TCF2 gene better known as HNF1-beta.

Test Strategy

In families with kidney dysplasias and type 2 diabetes this disease can be suspected. This suspicion would further supported if there is no association with metabolic syndrome in diabetic individuals.

Pathogenesis

The gene codes a transcription factor that is involved in cell regulation during kidney development and insulin secretion.

Systematic

MODY diabetes
	MODY1 diabetes
	MODY10 diabetes
	MODY11 diabetes
	MODY12 diabetes
	MODY13 diabetes
	MODY14 diabetes
	MODY2 diabetes
	MODY3 diabetes
	MODY4 diabetes
	MODY5 diabetes
		HNF1B
	MODY6 diabetes
	MODY7 diabetes
	MODY8 diabetes
	MODY9 diabetes