Permanent neonatal diabetes mellitus

Permanent neonatal diabetes mellitus (PNDM) is defined as an diabetes mellitus that starts within the first six month of life. Antenatal growth retardation, hyperglycemia, glycosuria, osmotic polyuria, severe dehydration, and failure to thrive are commonly accompanying features. Several genes are involved in PNDM. Inheritance is autosomal dominant (KCNJ11 and INS), autosomal dominant or recessive (ABCC8), and autosomal recessive (GCK and PDX1).

Systematic

Neonatal diabetes mellitus
	Leprechaunism
	Mitchell-Riley syndrome
	Neonatal diabetes mellitus with congenital hypothyroidism
	Pancreatogenic diabetes
	Permanent neonatal diabetes mellitus
		ABCC8
		Developmental delay, epilepsy, and neonatal diabetes
			KCNJ11
		GCK
		INS
		KCNJ11
		Phosphoribosylpyrophosphate synthetase superactivity
			PRPS1
		Wolcott-Rallison syndrome
			EIF2AK3
	Rabson-Mendenhall syndrome
	Renal cysts and diabetes (RCAD)
	Transient neonatal diabetes mellitus 1
	Transient neonatal diabetes mellitus 2
	Transient neonatal diabetes mellitus 3
	X-linked immunodysregulation, polyendocrinopathy, and enteropathy