Disturbances of vitamin K metabolism

if vitamin K metabolism is disturbed a bleeding disorder similar to wafarin medication ensues. A combined factor II, VII, IX, and X deficiency is observed.

Systematic

Hereditary bleeding disorders
	Afibrinogenemia
	Disturbances of vitamin K metabolism
		Combined deficiency of vitamin K-dependent clotting factors type 1
			GGCX
		Combined deficiency of vitamin K-dependent clotting factors type 2
			VKORC1
		Coumarin resistance
			CYP2A6
			CYP2C9
			CYP4F2
			VKORC1
		Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
			GGCX
	Dysfibrinogenemia
	Factor XII deficiency
	Factor XIII A subunit deficiency
	Factor XIII B subunit deficiency
	Plasminogen activator inhibitor deficiency

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