Clinical feature: 

Definition: Wolfram syndrome is generally characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. This form is caused by CISD2 mutations and exhibits an autosomal recessive pattern of inheritance.

Literature: 

Amr S et al. (2007) A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2.
Chen YF et al. (2009) Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.
El-Shanti H et al. (2000) Homozygosity mapping identifies an additional locus for Wolfram syndrome on chromosome 4q.