Laminin beta-2

Laminin beta-2 is an essential component of mature glomerular laminin, which is found in glomerular basement membrane. Homozygous mutations cause congenital nephrotic syndrome, Pierson syndrome.

Protein Structure

Laminins are large heterotrimer. Glomerular laminin changes its composition after birth. Fetal glomerular laminin, laminin-10, consists of (alpha-5:beta-1:gamma-1) and changes into (alpha-5:beta-2:gamma-1), called laminin-11. The component beta-2 that replaces beta-1 during maturation into laminin-11 is encoded by the LAMB2 gene.

Expression

Laminins have important functions in cellular differentiation and adhesion. Laminin-11 is an essential component of the glomerular basement membrane.

Genetests:

Related Diseases:

Congenital nephrotic syndrome type 05 (Pierson syndrome)
	LAMB2