Molecular genetic analysis (gene test): V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS)

KRAS
190070

Scheme

Mutations

Pedigree

Forms

Print page

Sprache
wechseln

V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog

Scientific background:

Summary: The KRAS gene encodes an importent protein in signal transduction. In 17-25% of human tumor cells a somatic activating mutation can be found. These mutations make make the cell resistant to GTPase activating peptides.

Methodology:

clinical test	Method	Genomic sequencing of the entire coding region
	Turn-around time	20 working days
	Effort	little
	Specimen	DNA
	Quality assessment	Internal quality control only
All known and new missense, nonsense and splice mutations can be detected.

Systematic link table:

Literature:

Ahrendt SA et al. (2001) Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Andreyev HJ et al. (1997) K-ras mutations in patients with early colorectal cancers.