Das somatische infantile kapilläre Hämangiom ist ein häufiger bei Neugeborenen und Kleinkindern gefundener benigner rötlicher Hauttumor. In den Tumoren finden sich somatische Mutationen in den Genen FLT4 und KDR.
Infantiles kapilläres Hämangiom | ||||
FLT4 | ||||
Infantiles kapilläres Hämangiom | ||||
FLT4 | ||||
Infantiles kapilläres Hämangiom mit Keimbahnmutation | ||||
1. |
Walter JW et al. (2002) Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. |
2. |
Blei F et al. (1998) Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait. |
3. |
Walter JW et al. (1999) Genetic mapping of a novel familial form of infantile hemangioma. |
4. |
Breugem CC et al. (2002) A locus for hereditary capillary malformations mapped on chromosome 5q. |
5. |
Ritter MR et al. (2002) Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. |
6. |
Waner M et al. (2003) The nonrandom distribution of facial hemangiomas. |
7. |
Spring MA et al. (2005) Cutaneous vascular lesions. |
8. |
Pramanik K et al. (2009) Dusp-5 and Snrk-1 coordinately function during vascular development and disease. |
9. |
Jinnin M et al. (2008) Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. |
10. |
OMIM.ORG article Omim 602089 |