C-Typ Lectin-Domän-Protein Familie 6 Member A
Das CLEC6A-Gen kodiert eine C-Typ Lectin-Protein, welches auch als Dectin-2 bekannt ist und und alpha-Mannan bindet, welches insbesondere in de Hyphae pathogener Pilze vorkommt. Es ist damit ein wichtiger Pathogen-Pattern-Rezeptor der angeborenen Immunität. Entsprechend führt ein Mangel dieses Enzyms zu schweren Pilzinfektionen.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Ritter M et al. (2010) Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.
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2. |
Schenten D et al. (2011) The control of adaptive immune responses by the innate immune system.
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3. |
Bi L et al. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.
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4. |
Kanazawa N et al. (2004) Molecular cloning of human dectin-2.
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5. |
Flornes LM et al. (2004) Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex.
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6. |
Gavino AC et al. (2005) Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2.
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7. |
Saijo S et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.
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8. |
Zhu LL et al. (2013) C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.
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9. |
Yonekawa A et al. (2014) Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.
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Update: 26. August 2020