Cytochrom P450 1A2

Schweikl H et al. (1993) Expression of CYP1A1 and CYP1A2 genes in human liver.

Browning SL et al. (2010) CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme.

Wooding SP et al. (2002) DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.

Rasmussen BB et al. (2002) The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors.

Christiansen L et al. (2000) Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.

Tantcheva-Poór I et al. (1999) Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.

Sachse C et al. (1999) Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine.

Nakajima M et al. (1999) Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.

Buters JT et al. (1996) Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2.

Liang HC et al. (1996) Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.

Paolini M et al. (1999) Co-carcinogenic effect of beta-carotene.

Shimada T et al. (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Devonshire HW et al. (1983) The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition.

None (1967) Acetophenetidin sensitivity.

Guengerich FP et al. (1986) Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation.

Sesardic D et al. (1988) A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.

Butler MA et al. (1989) Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Ikeya K et al. (1989) Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.

Vistisen K et al. (1992) Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine.