Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Das TLR5-Gen kodiert den Toll-like-Rezeptor 5, der sich auf der Außenseite der Zellmembran auf die Erkennung bakteriellen Flagellins spezialisiert hat. Genetische Veränderungen modulieren die Anfälligkeit gegenüber Infektionskrankheiten wie Melioidose und Legionärskrankheit aber auch gegenüber Lupus erythematodes.
| Klinisch | Untersuchungsmethoden | Familienuntersuchung |
| Bearbeitungszeit | 5 Tage | |
| Probentyp | genomische DNS |
| Klinisch | Untersuchungsmethoden | Hochdurchsatz-Sequenzierung |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| Forschung | Untersuchungsmethoden | Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| 1. |
Feuillet V et al. (2006) Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. 
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| 2. |
Fulde M et al. (2018) Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
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| 3. |
Zhang B et al. (2014) Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.
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| 4. |
West TE et al. (2013) Impaired TLR5 functionality is associated with survival in melioidosis.
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| 5. |
Yoon SI et al. (2012) Structural basis of TLR5-flagellin recognition and signaling.
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| 6. |
Vijay-Kumar M et al. (2010) Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
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| 7. |
Burdelya LG et al. (2008) An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.
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| 8. |
Vijay-Kumar M et al. (2007) Deletion of TLR5 results in spontaneous colitis in mice.
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| 9. |
Andersen-Nissen E et al. (2007) Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
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| 10. |
Andersen-Nissen E et al. (2007) A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.
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| 11. |
Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
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| 12. |
Hawn TR et al. (2005) A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus.
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| 13. |
Smith KD et al. (2003) Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility.
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| 14. |
Hawn TR et al. (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
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| 15. |
Deng J et al. (2009) Toll-like receptors 4 and 5 induce distinct types of vasculitis.
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| 16. |
Chaudhary PM et al. (1998) Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.
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| 17. |
Hayashi F et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
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| 18. |
Muzio M et al. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.
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| 19. |
Rock FL et al. (1998) A family of human receptors structurally related to Drosophila Toll.
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