IRF5-Gen
Das IRF5-Gen kodiert einen Interferon regulierenden Faktor. Genetische Veränderungen werden mit entzündlichen Darmerkrankungen und eine Anfälligkeit für Lupus erythematodes verantwortlich gemacht.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Akilesh HM et al. (2019) Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
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2. |
Taniguchi T et al. (2001) IRF family of transcription factors as regulators of host defense.
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3. |
Barnes BJ et al. (2001) Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.
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4. |
Barnes BJ et al. (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes.
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5. |
Morley M et al. (2004) Genetic analysis of genome-wide variation in human gene expression.
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6. |
Sigurdsson S et al. (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
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7. |
Takaoka A et al. (2005) Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.
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8. |
Graham RR et al. (2006) A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
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9. |
Cunninghame Graham DS et al. (2007) Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
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10. |
Yanai H et al. (2007) Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.
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11. |
Kozyrev SV et al. (2007) Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus.
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12. |
Reddy MV et al. (2007) Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans.
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13. |
Sigurdsson S et. al. (2007) Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
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14. |
Dideberg V et al. (2007) An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
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15. |
Sigurdsson S et al. (2008) Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.
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16. |
Couzinet A et al. (2008) A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis.
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Update: 3. November 2022