STAT4-Gen
Das vom STAT4-Gen kodierte Protein ist für die Signaltransduktion vom Interleukin 12 verantwortlich. Genetische Veränderungen sind für die Anfälligkeit gegenüber Lupus erythematodes Typ 11 verantwortlich.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Diefenbach A et al. (1999) Requirement for type 2 NO synthase for IL-12 signaling in innate immunity.
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2. |
Yamamoto K et al. (1997) cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
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3. |
Frucht DM et al. (2000) Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.
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4. |
Lovato P et al. (2003) Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease.
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5. |
Ota N et al. (2004) N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.
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6. |
Yap WH et al. (2005) STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.
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7. |
Shin HJ et al. (2005) STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism.
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8. |
Remmers EF et al. (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
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9. |
Pang YH et al. (2007) Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.
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10. |
Kariuki SN et al. (2009) Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
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11. |
Han JW et al. (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
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12. |
Gateva V et al. (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
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Update: 3. November 2022