Transient neonatal diabetes mellitus is an autosomal dominant disorder caused by mutations of the ABCC8 gene. The clinical variation within a family can vary significantly from transient or permanent neonatal diabetes mellitus to a typical type 2 diabetes of adulthood.
The disease is cause by an activating mutation of the ABCC8 gene.
The disease can be treated by sulfonyl urea.
1. |
Babenko AP et al. (2006) Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. |
2. |
OMIM.ORG article Omim 610374 |