Fanconi-type hypophosphatemic rickets is a group of disorders caused by unspecific proximal tubular damage. Because the filtrated phosphate is reabsorbed in the proximal tubule almost all proximal tubular dysfunction is accompanied by hyperphosphaturia. Some of them are known to cause bone disease. Accompanying symptoms include the typical features of Fanconi syndrome including low-molecular-weight proteinuria, glucosuria, or proximal tubular acidosis.
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