Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Body mass index quantitative trait

The group includes all genetic loci that can effect body stature as measured by the body mass index (BMI).

Systematic

Obesity
Autosomal dominant obesity
Body mass index quantitative trait
BMI effecting trait 14
FTO
Early-onset obesity
Late-onset obesity
Severe obesity
Severe obesity and type 2 diabetes
Susceptibility to obesity

References:

1.

Masud S et al. (2003) Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis.

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2.

Locke AE et al. (2015) Genetic studies of body mass index yield new insights for obesity biology.

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3.

Shungin D et al. (2015) New genetic loci link adipose and insulin biology to body fat distribution.

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4.

Kilpeläinen TO et al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

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5.

Speliotes EK et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

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6.

Walley AJ et al. (2009) The genetic contribution to non-syndromic human obesity.

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7.

Yanagiya T et al. (2007) Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.

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8.

Platte P et al. (2003) A study of linkage and association of body mass index in the Old Order Amish.

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9.

Atwood LD et al. (2002) Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study.

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10.

Feitosa MF et al. (2002) Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study.

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11.

Hsueh WC et al. (2001) Genome-wide scan of obesity in the Old Order Amish.

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12.

Valve R et al. (1999) Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.

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13.

Rice T et al. (1999) Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Québec family study.

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14.

Deeb SS et al. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

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15.

Hanson RL et al. (1998) An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.

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16.

Hallstrand TS et al. (2005) Genetic pleiotropy between asthma and obesity in a community-based sample of twins.

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17.

Meyre D et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

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18.

OMIM.ORG article

Omim 606641 external link
Update: Aug. 14, 2020
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