Apolipoprotein F
The APOF gene encodes apolipoprotein F, a protein formerly known as lipid transfer inhibitor protein (LTIP), is synthesized by the liver and activated in the circulation. It inhibits the CETP and LCAT probably in a way to control the direction of lipid transfer. The activation of apolipoprotein F depends on the composition of LDL particles. While apolipoprotein F deficiency did not significantly alter the lipid profile, overexpression reduces HDL.
Genetests:
Research |
Method |
Carrier testing |
Turnaround |
5 days |
Specimen type |
genomic DNA |
Related Diseases:
References:
1. |
Lagor WR et al. (2009) Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.
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2. |
Olofsson SO et al. (1978) Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma.
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3. |
Lagor WR et al. (2012) The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
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4. |
Koren E et al. (1982) Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma.
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5. |
Day JR et al. (1994) Purification and molecular cloning of human apolipoprotein F.
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6. |
Wang X et al. (1999) Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F.
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7. |
OMIM.ORG article
Omim 107760
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8. |
NCBI article
NCBI 319
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9. |
Wikipedia article
Wikipedia EN (APOF)
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Update: Aug. 14, 2020