Glucose-6-phosphatase 2
The G6PC2 gene encodes an islet-specific glucose-6-phophatase, which seems to be involved in blood sugar regulation. The protein is a trarget antigen in autoimmune diabetes type 1 and polymorphisms seem to influence fasting glucose levels.
Genetests:
Related Diseases:
References:
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Neophytou PI et al. (1996) A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells.
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DiLorenzo TP et al. (1998) Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement.
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3. |
Arden SD et al. (1999) Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
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4. |
Ebert DH et al. (1999) Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
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Martin CC et al. (2001) Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes.
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6. |
Pociot F et al. (2002) Genetics of type 1 diabetes mellitus.
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Lieberman SM et al. (2003) Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
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8. |
Hutton JC et al. (2003) A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes.
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9. |
NCBI article
NCBI 57818
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10. |
OMIM.ORG article
Omim 608058
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11. |
Wikipedia article
Wikipedia EN (G6PC2)
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Update: Aug. 14, 2020