Forkhead box protein P3
The FOXP3 gene encodes a transcription factor that is expressed during maturation of some regulator T lymphocytes. Mutations cause x-linked recessive immunodeficiency, polyendocrinopathy, and enteropathy.
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References:
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Pan F et al. (2009) Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.
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2. |
Gavin MA et al. (2007) Foxp3-dependent programme of regulatory T-cell differentiation.
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Wan YY et al. (2007) Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression.
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4. |
Zheng Y et al. (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.
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5. |
Marson A et al. (2007) Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
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6. |
Ono M et al. (2007) Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.
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7. |
Zuo T et al. (2007) FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
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8. |
Zuo T et al. (2007) FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.
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9. |
Ricciardelli I et al. (2008) Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease.
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10. |
Lund JM et al. (2008) Coordination of early protective immunity to viral infection by regulatory T cells.
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11. |
Zheng Y et al. (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.
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12. |
Tsuji M et al. (2009) Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.
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13. |
Feuerer M et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
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14. |
Suzuki S et al. (2007) Molecular basis of neonatal diabetes in Japanese patients.
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15. |
Casetti R et al. (2009) Cutting edge: TGF-beta1 and IL-15 Induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulation.
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16. |
Lanteri MC et al. (2009) Tregs control the development of symptomatic West Nile virus infection in humans and mice.
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17. |
Zheng Y et al. (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.
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18. |
Toulza F et al. (2010) Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells.
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19. |
Liu B et al. (2010) The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
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20. |
Mold JE et al. (2010) Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.
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21. |
Rowe JH et al. (2011) Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens.
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22. |
Dang EV et al. (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
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23. |
Rowe JH et al. (2012) Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.
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24. |
Huang C et al. (2013) Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28.
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25. |
Sharma MD et al. (2013) An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.
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26. |
Smigiel KS et al. (2014) CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets.
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27. |
Pennington DJ et al. (2006) Early events in the thymus affect the balance of effector and regulatory T cells.
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28. |
Hori S et al. (2003) Control of regulatory T cell development by the transcription factor Foxp3.
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29. |
Lyon MF et al. (1990) The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.
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30. |
Powell BR et al. (1982) An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy.
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31. |
Clark LB et al. (1999) Cellular and molecular characterization of the scurfy mouse mutant.
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32. |
Ferguson PJ et al. (2000) Manifestations and linkage analysis in X-linked autoimmunity-immunodeficiency syndrome.
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33. |
Chatila TA et al. (2000) JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.
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34. |
Wildin RS et al. (2001) X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.
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35. |
Bennett CL et al. (2001) The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
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36. |
Brunkow ME et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
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37. |
Levy-Lahad E et al. (2001) Neonatal diabetes mellitus, enteropathy, thrombocytopenia, and endocrinopathy: Further evidence for an X-linked lethal syndrome.
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38. |
Owen CJ et al. (2003) Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome.
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39. |
Khattri R et al. (2001) The amount of scurfin protein determines peripheral T cell number and responsiveness.
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40. |
Fontenot JD et al. (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
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41. |
Khattri R et al. (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells.
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42. |
Bassuny WM et al. (2003) A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes.
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43. |
Miura Y et al. (2004) Association of Foxp3 regulatory gene expression with graft-versus-host disease.
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44. |
Stock P et al. (2004) Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity.
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45. |
Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
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46. |
Wan YY et al. (2005) Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.
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47. |
Hong J et al. (2005) Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.
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48. |
Allan SE et al. (2005) The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.
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49. |
Bacchetta R et al. (2006) Defective regulatory and effector T cell functions in patients with FOXP3 mutations.
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50. |
Smith EL et al. (2006) Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation.
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51. |
Lahl K et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
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52. |
OMIM.ORG article
Omim 300292
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53. |
Orphanet article
Orphanet ID 121913
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54. |
NCBI article
NCBI 50943
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55. |
Wikipedia article
Wikipedia EN (FOXP3)
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Update: Aug. 14, 2020