Mitogen-activated protein kinase 8-interacting protein 1
The MAPK8IP1 gene encodes a protein that regulates beta cell function. Mutations cause a susceptibility to diabetes type 2 in a dominant fashion.
Genetests:
Related Diseases:
References:
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Taru H et al. (2002) Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.
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Mooser V et al. (1999) Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene.
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Yasuda J et al. (1999) The JIP group of mitogen-activated protein kinase scaffold proteins.
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Waeber G et al. (2000) The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.
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Bonny C et al. (2000) IB1 reduces cytokine-induced apoptosis of insulin-secreting cells.
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Thompson NA et al. (2001) Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice.
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Whitmarsh AJ et al. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation.
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8. |
Abderrahmani A et al. (2001) The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).
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Jaeschke A et al. (2004) An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
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10. |
NCBI article
NCBI 9479
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OMIM.ORG article
Omim 604641
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12. |
Wikipedia article
Wikipedia EN (MAPK8IP1)
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Update: Aug. 14, 2020