Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The SERPINA10 gene encodes a proteinase inhibitor which with its cofactor protein Z inhibits activated coagulations factors Xa and XIa. Inactivating mutations may promote thrombophilia.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Yin ZF et al. (2000) Prothrombotic phenotype of protein Z deficiency. 
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| 2. |
Han X et al. (1998) Isolation of a protein Z-dependent plasma protease inhibitor.
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| 3. |
New L et al. (1996) cDNA cloning of rasp-1, a novel gene encoding a plasma protein associated with liver regeneration.
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| 4. |
Han X et al. (1999) The protein Z-dependent protease inhibitor is a serpin.
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| 5. |
Van de Water N et al. (2004) Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia.
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| 6. |
NCBI article NCBI 51156
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| 7. |
OMIM.ORG article Omim 605271
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| 8. |
Wikipedia article Wikipedia EN (Protein_Z-related_protease_inhibitor)
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