Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The TNIP1 gene encodes a protein that is involved in transcription control. Mutations are found in autoimmune diseases such as psoriatric and rheumatoid arthritis and lupus erythematodes. Epigenetic modification of this gene was associated with dyslipidemia.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Braun KV et al. (2016) The role of DNA methylation in dyslipidaemia: A systematic review. 
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| 2. |
Pfeiffer L et al. (2015) DNA methylation of lipid-related genes affects blood lipid levels.
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| 3. |
Fukushi M et al. (1999) Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression.
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| 4. |
Zhang S et al. (2002) A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling.
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| 5. |
El Bakkouri K et al. (2005) Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model.
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| 6. |
Oshima S et al. (2009) ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
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| 7. |
Gurevich I et al. (2009) Liganded RARalpha and RARgamma interact with but are repressed by TNIP1.
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| 8. |
Orphanet article Orphanet ID 369132
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| 9. |
NCBI article NCBI 10318
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| 10. |
OMIM.ORG article Omim 607714
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| 11. |
Wikipedia article Wikipedia EN (TNIP1)
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