Endothelial lipase
The LIPG gene encodes a lipase which is involved in intravascular lipolysis. Therefore it is a probably candidate for mutation in hypertriglyceridemia.
Genetests:
Related Diseases:
References:
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Cefalù AB et al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.
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2. |
Jaye M et al. (1999) A novel endothelial-derived lipase that modulates HDL metabolism.
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3. |
Hirata K et al. (1999) Cloning of a unique lipase from endothelial cells extends the lipase gene family.
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4. |
Ishida T et al. (2003) Endothelial lipase is a major determinant of HDL level.
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5. |
Jin W et al. (2003) Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo.
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6. |
Yamakawa-Kobayashi K et al. (2003) Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children.
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7. |
Ishida T et al. (2004) Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms.
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8. |
Ishida T et al. (2004) Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice.
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9. |
NCBI article
NCBI 9388
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10. |
OMIM.ORG article
Omim 603684
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11. |
Wikipedia article
Wikipedia EN (Endothelial_lipase)
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Update: Aug. 14, 2020