Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The IL17RC gene encodes a transmembrane protein, interleukin-17 receptor C, which is predominantly expressed on non-hematopoetic cells. The receptor has implications on inflammatory and autoimmune processes. Mutations cause autosomal recessive Candidiasis 9.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Toy D et al. (2006) Cutting edge: interleukin 17 signals through a heteromeric receptor complex. 
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| 2. |
Haudenschild D et al. (2002) Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer.
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| 3. |
Ho AW et al. (2010) IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.
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| 4. |
Ling Y et al. (2015) Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
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