Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The IRAK1 gene encodes a protein, interleukin-1 receptor-associated kinase, which is involved in signal transdaction of the Interleukin 1 induces transcrription of NF-kappa-B. Genetic variants are thought to be involved in lupus erythematosus susceptibility type 15
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Cao Z et al. (1996) IRAK: a kinase associated with the interleukin-1 receptor. 
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| 2. |
Kanakaraj P et al. (1999) Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.
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| 3. |
Thomas JA et al. (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.
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| 4. |
Zhande R et al. (2007) FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction.
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| 5. |
Jacob CO et al. (2009) Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
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| 6. |
Chassin C et al. (2010) miR-146a mediates protective innate immune tolerance in the neonate intestine.
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