PDCD1 gene
The encodes a protein, programmed cell death protein 1, that is at several points involved in downregulation of immune responses. Genetic variantion are suspected to be involved in lupus erythematosus susceptibility type 2 and multiple sclerosis.
Genetests:
Related Diseases:
References:
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Lázár-Molnár E et al. (2008) The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.
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Sugiura D et al. (2019) {'i': ['cis'], 'content': 'Restriction of PD-1 function by -PD-L1/CD80 interactions is required for optimal T cell responses.'}
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3. |
Meng X et al. (2018) FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
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4. |
Wartewig T et al. (2017) PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
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Le DT et al. (2017) Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
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Gordon SR et al. (2017) PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
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7. |
George S et al. (2017) Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma.
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8. |
Sen DR et al. (2016) The epigenetic landscape of T cell exhaustion.
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Pauken KE et al. (2016) Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.
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10. |
Yang W et al. (2013) Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia.
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11. |
Kawamoto S et al. (2012) The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut.
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Quigley M et al. (2010) Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
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13. |
Dai H et al. (2010) Cutting edge: programmed death-1 defines CD8+CD122+ T cells as regulatory versus memory T cells.
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14. |
Said EA et. al. (2010) Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection.
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15. |
Day CL et al. (2006) PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
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16. |
Barber DL et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection.
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Okazaki T et al. (2005) Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
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18. |
Kroner A et al. (2005) A PD-1 polymorphism is associated with disease progression in multiple sclerosis.
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19. |
Okazaki T et al. (2003) Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice.
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20. |
Prokunina L et al. (2002) A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.
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21. |
Latchman Y et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
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22. |
Nishimura H et al. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
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23. |
Freeman GJ et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
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24. |
Finger LR et al. (1997) The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors.
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25. |
Shinohara T et al. (1994) Structure and chromosomal localization of the human PD-1 gene (PDCD1).
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26. |
Ishida Y et al. (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
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Update: Nov. 3, 2022