STAT4 gene

Diefenbach A et al. (1999) Requirement for type 2 NO synthase for IL-12 signaling in innate immunity.

Yamamoto K et al. (1997) cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.

Frucht DM et al. (2000) Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.

Lovato P et al. (2003) Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease.

Ota N et al. (2004) N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.

Yap WH et al. (2005) STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.

Shin HJ et al. (2005) STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism.

Remmers EF et al. (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Pang YH et al. (2007) Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.

Kariuki SN et al. (2009) Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.

Han JW et al. (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

Gateva V et al. (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.