Der TRH-Mangel ist eine autosomal rezessive Erkrankung, die durch Mutationen im TRH-Gen ausgelöst wird.
Zentrale Hypothyreose | ||||
Generalisierte TRH-Resistenz | ||||
TRH-Mangel | ||||
TRH | ||||
Zentrale Hypothyreose und Makroorchidie | ||||
1. |
Mitnick M et al. (1972) Enzymatic synthesis of thyrotropin releasing hormone (TRH) by hypothalamic "TRH synthetase". |
2. |
Foresti V et al. (1985) Central hypothyroidism: isolated thyrotropin-releasing hormone deficiency or resistance of pituitary thyrotropes? |
3. |
Katakami H et al. (1984) Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency. |
4. |
Niimi H et al. (1982) Congenital isolated thyrotrophin releasing hormone deficiency. |
5. |
OMIM.ORG article Omim 275120 |