LDL-Rezeptor-related-Protein 5

Van Wesenbeeck L et al. (2003) Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.

Cui Y et al. (2011) Lrp5 functions in bone to regulate bone mass.

Narumi S et al. (2010) Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: identification of a 7.2-kb microdeletion using oligonucleotide tiling microarray.

Yadav VK et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.

Qin M et al. (2008) Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy.

Guo YF et al. (2006) Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study.

Clément-Lacroix P et al. (2005) Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice.

Ai M et al. (2005) Clinical and molecular findings in osteoporosis-pseudoglioma syndrome.

Qin M et al. (2005) Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes.

Semënov M et al. (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

Jiao X et al. (2004) Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5.

Ferrari SL et al. (2004) Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites.

Toomes C et al. (2004) Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

Mizuguchi T et al. (2004) LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density.

Kondo H et al. (2003) Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity.

Fujino T et al. (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion.

Magoori K et al. (2003) Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.

None (1995) Familial exudative vitreoretinopathy.

Shastry BS et al. (1997) Familial exudative vitreoretinopathy: further evidence for genetic heterogeneity.

Hey PJ et al. (1998) Cloning of a novel member of the low-density lipoprotein receptor family.

Dong Y et al. (1998) Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity.

de Crecchio G et al. (1998) Autosomal recessive familial exudative vitreoretinopathy: evidence for genetic heterogeneity.

Chen D et al. (1999) Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human.

Mao J et al. (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

Twells RC et al. (2001) The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13.

Gong Y et al. (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Little RD et al. (2002) A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.

Kato M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor.

Boyden LM et al. (2002) High bone density due to a mutation in LDL-receptor-related protein 5.

Twells RC et al. (2003) Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.

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NCBI article

OMIM.ORG article