Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The TLR5 gene encodes a receptor of bacterial flagellin located outside the cell membrane. Genetic variants modulate susceptibility to various infectionous diseases such as melioidosis and Legionnaire disease and lupus erythematosus.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Feuillet V et al. (2006) Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. 
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| 2. |
Fulde M et al. (2018) Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
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| 3. |
Zhang B et al. (2014) Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.
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| 4. |
West TE et al. (2013) Impaired TLR5 functionality is associated with survival in melioidosis.
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| 5. |
Yoon SI et al. (2012) Structural basis of TLR5-flagellin recognition and signaling.
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| 6. |
Vijay-Kumar M et al. (2010) Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
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| 7. |
Burdelya LG et al. (2008) An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.
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| 8. |
Vijay-Kumar M et al. (2007) Deletion of TLR5 results in spontaneous colitis in mice.
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| 9. |
Andersen-Nissen E et al. (2007) Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
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| 10. |
Andersen-Nissen E et al. (2007) A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.
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| 11. |
Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
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| 12. |
Hawn TR et al. (2005) A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus.
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| 13. |
Smith KD et al. (2003) Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility.
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| 14. |
Hawn TR et al. (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
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| 15. |
Deng J et al. (2009) Toll-like receptors 4 and 5 induce distinct types of vasculitis.
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| 16. |
Chaudhary PM et al. (1998) Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.
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| 17. |
Hayashi F et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
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| 18. |
Muzio M et al. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.
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| 19. |
Rock FL et al. (1998) A family of human receptors structurally related to Drosophila Toll.
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