Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Toll-like receptor 7

The TLR7 gene encodes a receptor of single-standed RNA located in endosomes of dendritic cells. Mutations cause X-linked susceptibility to Covid-19 infections.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Immunodeficiency 74, COVID19-related
TLR7
TLR8

References:

1.

Pisitkun P et al. (2006) Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.

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2.

Akilesh HM et al. (2019) Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.

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3.

Kasturi SP et al. (2011) Programming the magnitude and persistence of antibody responses with innate immunity.

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4.

Baumann CL et al. (2010) CD14 is a coreceptor of Toll-like receptors 7 and 9.

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5.

Shen N et al. (2010) Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus.

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6.

Guiducci C et al. (2010) TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

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7.

Meier A et al. (2009) Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.

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8.

Town T et al. (2009) Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.

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9.

Hayashi T et al. (2009) Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.

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10.

Delgado MF et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.

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11.

Ewald SE et al. (2008) The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

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12.

Lee HK et al. (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells.

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13.

Subramanian S et al. (2006) A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.

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14.

Du X et al. (2000) Three novel mammalian toll-like receptors: gene structure, expression, and evolution.

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15.

Lee J et al. (2006) Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

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16.

Yang K et al. (2005) Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

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17.

Lau CM et al. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

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18.

Horsmans Y et al. (2005) Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection.

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19.

Hornung V et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.

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20.

Heil F et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

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21.

Diebold SS et al. (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

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22.

Nagase H et al. (2003) Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand.

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23.

Lee J et al. (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.

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24.

Hemmi H et al. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.

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25.

Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

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26.

Chuang TH et al. (2000) Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.

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Update: Nov. 3, 2022
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