Toll-like receptor 7
The TLR7 gene encodes a receptor of single-standed RNA located in endosomes of dendritic cells. Mutations cause X-linked susceptibility to Covid-19 infections.
Genetests:
Related Diseases:
References:
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Pisitkun P et al. (2006) Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.
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Akilesh HM et al. (2019) Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
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Kasturi SP et al. (2011) Programming the magnitude and persistence of antibody responses with innate immunity.
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Baumann CL et al. (2010) CD14 is a coreceptor of Toll-like receptors 7 and 9.
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5. |
Shen N et al. (2010) Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus.
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6. |
Guiducci C et al. (2010) TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.
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7. |
Meier A et al. (2009) Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.
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8. |
Town T et al. (2009) Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.
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9. |
Hayashi T et al. (2009) Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.
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10. |
Delgado MF et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.
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11. |
Ewald SE et al. (2008) The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.
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12. |
Lee HK et al. (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells.
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13. |
Subramanian S et al. (2006) A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.
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14. |
Du X et al. (2000) Three novel mammalian toll-like receptors: gene structure, expression, and evolution.
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15. |
Lee J et al. (2006) Activation of anti-hepatitis C virus responses via Toll-like receptor 7.
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16. |
Yang K et al. (2005) Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.
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Lau CM et al. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
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18. |
Horsmans Y et al. (2005) Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection.
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Hornung V et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
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Heil F et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
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Diebold SS et al. (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
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22. |
Nagase H et al. (2003) Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand.
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23. |
Lee J et al. (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.
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24. |
Hemmi H et al. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
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25. |
Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
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26. |
Chuang TH et al. (2000) Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.
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Update: Nov. 3, 2022