Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The TLR8 gene encodes a receptor of single-standed RNA located in endosomes of dendritic cells. Because of similar function and specificity it is assumed that in TLR8 like in TLR7 may cause susceptibility to RNA virus infections.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Du X et al. (2000) Three novel mammalian toll-like receptors: gene structure, expression, and evolution. 
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| 2. |
Chuang TH et al. (2000) Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.
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| 3. |
Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
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| 4. |
Heil F et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
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| 5. |
Yang K et al. (2005) Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.
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| 6. |
Peng G et al. (2005) Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.
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| 7. |
Tanji H et al. (2013) Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.
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