Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Das BMP7-Gen kodiert ein Protein in dem TGP-beta-Signalweg und ist bei der Steuerung der Knochenbildung beteiligt. Dass Mutationen zu Nierenfehlbildungen führen können, wird ebenfalls diskutiert.
| Klinisch | Untersuchungsmethoden | Familienuntersuchung |
| Bearbeitungszeit | 5 Tage | |
| Probentyp | genomische DNS |
| Klinisch | Untersuchungsmethoden | Hochdurchsatz-Sequenzierung |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| Forschung | Untersuchungsmethoden | Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| 1. |
Fuller ML et al. (2007) Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. 
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| 2. |
Long J et al. (2013) MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
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| 3. |
Kazama I et al. (2008) Podocyte-derived BMP7 is critical for nephron development.
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| 4. |
Tseng YH et al. (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
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| 5. |
Adams D et al. (2007) Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species.
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| 6. |
Suzuki K et al. (2008) Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4.
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| 7. |
Zeisberg EM et al. (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.
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| 8. |
Wang S et al. (2004) Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells.
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| 9. |
Butler SJ et al. (2003) A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.
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| 10. |
Groppe J et al. (2002) Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.
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| 11. |
You L et al. (2002) Differential effect of activin A and BMP-7 on myofibroblast differentiation and the role of the Smad signaling pathway.
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| 12. |
Beck HN et al. (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons.
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| 13. |
Augsburger A et al. (1999) BMPs as mediators of roof plate repulsion of commissural neurons.
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| 14. |
Jena N et al. (1997) BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye.
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| 15. |
Solursh M et al. (1996) Osteogenic protein-1 is required for mammalian eye development.
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| 16. |
Dudley AT et al. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
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| 17. |
Marker PC et al. (1995) Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2.
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| 18. |
Ozkaynak E et al. (1990) OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.
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| 19. |
Celeste AJ et al. (1990) Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
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| 20. |
Hahn GV et al. (1992) A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7.
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| 21. |
Cheng H et al. (2003) Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).
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| 22. |
NCBI article NCBI 655
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| 23. |
OMIM.ORG article Omim 112267
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